Does İsotretinoin (ISO) Therapy İncrease Coagulation Tendency? Evaluation of MPV values and MPV / platelet rate

Author Details : Pinar Ozuguz, M. Sena Ulu, Seval Dogruk Kacar, Ufuk Ozuguz, Semsettin Karaca

Volume : 1, Issue : 1, Year : 2015

Article Page : 14-16

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Introduction/ Purpose: Mean Platelet Volume (MPV), an indicator of platelet activation, is a new risk factor for atherothrombosis and an important marker for the increase in thromboembolic diseases. MPV/ platelet ratio is considered as a risk factor for various diseases such as myocardial infarction. In this study, we aimed to investigate the possible effect of ISO on blood cell counts especially MPV and MPV/ platelet ratio.
Materials and Methods: 75 patients, between the ages of 18-25 with moderate or severe acne vulgaris and using oral isotretinoin (0.5 mg/ kg) were included in the study. Platelet count ​​and MPV values of patients (pre-treatment and 3 months after the treatment) were recorded retrospectively.
Results: The mean age of patients was 23.32+3.44 years. 40 patients were female and 35 were male. MPV levels and MPV/ p ratio of “before treatment period” were significantly higher than the “after treatment period” (p Conclusion: In the literature, alteration in platelet levels under ISO treatment is a controversial issue. Furthermore, it was emphasized that, ISO treatment may be change platelet functions. In our study, MPV values and MPV / p ratio were decreased after ISO treatment. Our data indicates that, the thromboembolic risk of patients with acne vulgaris may reduce after ISO treatment.

Acne vulgaris, İsotretinoin, MPV, PlateletThromboembolism risk

How to cite : Ozuguz P, Ulu M S, Kacar S D, Ozuguz U, Karaca S, Does İsotretinoin (ISO) Therapy İncrease Coagulation Tendency? Evaluation of MPV values and MPV / platelet rate. IP Indian J Clin Exp Dermatol 2015;1(1):14-16

Copyright © 2015 by author(s) and IP Indian J Clin Exp Dermatol. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

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