Clinico-pathological correlation of linear dermatoses along the lines of Blaschko: An observational study

Original Article

Author Details : Shilpa V Dastikop, Manjunath S, Naveen Manohar, Gajanan A Pise*, Malteshgauda N Patil

Volume : 7, Issue : 4, Year : 2021

Article Page : 288-295

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Background: Several epidemiological studies have described linear dermatoses; however, only few studies have correlated linear dermatoses along Blaschko’s lines with the histopathological findings. The aims of this study were to investigate the clinical patterns of various linear dermatological lesions along Blaschko’s lines and investigate the correlations between these dermatological lesions and their histopathological features.
Materials and Methods: Patients who attended our dermatology out-patient department with linear dermatoses along the Blaschko’s lines were included in the study. Detailed history was obtained, clinical examination was performed, and a final provisional clinical diagnosis was noted. Subsequently, biopsy of the lesions was performed for histopathological examination. Of 62 patients who presented with linear lesions along the Blaschko’s lines, 45 patients underwent biopsy and histopathological examination.
Results: Of 45 patients who underwent biopsy, clinico-pathological correlation was observed in 100% of those diagnosed with lichen striatus and linear morphea, 89% of those diagnosed with hypomelanosis of Ito, 80% of those diagnosed with linear epidermal nevus, 75% of those diagnosed with lichen planus, and 67% of those diagnosed with nevus depigmentosus.
Conclusions The importance of correlation of linear lesions with their histopathological features in dermatology cannot be over emphasized. However, 100% correlation may be wishful thinking, and a correlation can help choose the appropriate line of management. Our results highlight this discrepancy and add to the knowledge on linear dermatosis.

Keywords: Blaschko's lines, Linear lesions, Lichen striatus

How to cite : Dastikop S V, Manjunath S, Manohar N, Pise G A, Patil M N, Clinico-pathological correlation of linear dermatoses along the lines of Blaschko: An observational study. IP Indian J Clin Exp Dermatol 2021;7(4):288-295

Copyright © 2021 by author(s) and IP Indian J Clin Exp Dermatol. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

Article History

Received : 15-09-2021

Accepted : 07-10-2021

Available online : 11-12-2021

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