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The association of metabolic syndrome and insulin resistance in early-onset androgenetic alopecia in males: a case-control study
- Author Details:
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M. Ranga Swaroop
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Manohara BK
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BD Sathyanarayana
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Yogesh D
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Raghavendra JC
Introduction: Men with premature androgenetic alopecia (AGA) are found to be susceptible to cardiovascular diseases, metabolic syndrome, diabetes mellitus and hypertension and also premature baldness can have a definite negative impact on self-image and self-esteem in these patients. Insulin resistance (IR), metabolic syndrome (MS) are known to be independent risk factors for coronary heart disease (CHD). The aim of this study was to assess the strength of association between MS and/or insulin resistance in males with early-onset Androgenetic alopecia (AGA).
Methods: A total of 50 male patients with premature AGA attending the dermatology out-patient department and satisfying the inclusion and exclusion criteria were recruited in the study. Equal number of normal age and gender matched patients attending the dermatology OPD were taken as control group. A detailed history of the patients as per the prepared questionnaire was taken. Elaborate general, physical and systemic examination were carried out and recorded in standard proforma. Complete examination of scalp was done with emphasis on pattern and severity of hair loss. Hair loss was graded according to Hamilton-Norwood scale. Anthropometric and blood pressure measurement was done according to structured proforma. Fasting blood samples were collected and fasting insulin level, fasting blood sugar levels, high density lipoproteins, triglycerides were determined.
Results: In this study, majority of patients with early onset AGA were in the age group of 22-24 years. Most common grade of hair loss was grade III a (32%) of Hamilton- Norwood scale of hair loss. 5 out of 50 cases (10%) and 2 out of 50 controls (4%) had shown association with insulin resistance and the difference between the groups was statistically insignificant (p= 0.23). 15 out of 50 cases (30%) and 4 out of 50 controls had shown association with metabolic syndrome and the difference between the group was statistically significant (p= 0.005).
Conclusion: In our study, majority of patients with early onset AGA were in age group 22-24 years. 31% of cases had family history of AGA. Majority of the patients had stage III of Hamilton-Norwood scale of hair loss. Male patients with early onset AGA were not associated with IR. Metabolic syndrome was associated with male patients with early onset AGA.
Keywords: Early-onset androgenetic alopecia, Insulin resistance, Metabolic syndrome
References
- Wadhwa SL, Khopkar U, Nischal KC. Hair and scalp disorders. In: Valia RG, Valia RA, editors. IADVL Textbook of Dermatology. 3 rd ed. Mumbai: Bhalani Publishing House; 2008. p. 887-9. M. Ranga Swaroop et al. The association of metabolic syndrome and insulin resistance in early-onset…. Indian Journal of Clinical and Experimental Dermatology, October-December 2016;2(4):159-163 163
- Narad S, Pande S, Guptha M, Chari S. Hormonal profile in Indian men with premature androgenetic alopecia. Int J Trichol 2013;5(2):69-72.
- Acibucu F, Kayatas M, Candan F. The association of insulin resistance and metabolic syndrome in early androgenetic alopecia. Singapore Med J 2010;51(12):931-
- Bakry OA, Shoeib MM, ElShafiee MK, Hassan A. Androgenetic alopecia, metabolic syndrome, and insulin resistance: Is there any association? A case-control study. Indian Dermatol online J [serial online] 2014 [cited 2014 Oct 01];5:276 -81. Available from: http://www.idoj.in/text.asp?2014/5/3/276/137776.
- Gonzalez-Gonzalez JG, Mancillas-Adame LG, Fernandez- Reyes M, Gomez-Flores M, Lavalle-Gonzalez FJ, Ocampo-Candiani J et al. Androgenetic alopecia and insulin resistance in young men. Clin Endocrinol (Oxf) 2009 Oct;71(4):494-9.
- Chakrabarty S, Hariharan R, Gowda DG, Suresh H. Association of Premature Androgenetic Alopecia and Metabolic Syndrome in a Young Indian Population. Int J Trichology 2014 Apr-Jun;6(2):50-3.
- Mumcuoglu C, Ekmekci TR, Ucak S. The investigation of insulin resistance and metabolic syndrome in male patients with early-onset androgenetic alopecia. Eur J Dermatol 2011 Jan-Feb;21(1):79-82.
- Yang CC, Hsieh FN, Lin LY, Hsu CK, Sheu HM, Chen WC. Higher body mass index is associated with greater severity of alopecia in men with male-pattern androgenetic alopecia in Taiwan: A cross-sectional study. J Am Acad Dermatol 2014 Feb;70(2):297-302.
- Pengsalae N, Tanglertsampan C, Phichawong T, Lee S. Association of early-onset androgenetic alopecia and metabolic syndrome in Thai men: A case-control study. J Med Assoc Thai 2013 Aug;96(8):947-51.
- Abdel Fattah NS, Darwish YW. Androgenetic alopecia and insulin resistance: are they truly associated? Int J Dermatol 2011 Apr;50(4):417-22.
- Matilainen V, Koskela P, Keinanen-Kiukaanniemi S. Early androgenetic alopecia as a marker of insulin resistance. Lancet 2000;356:1165-6.
- Hirsso P, Laakso M, Matilainen V, Hiltunen L, Rajala U, Jokelainen J, et al. Association of insulin resistance-linked diseases and hair loss in elderly men. Finnish population- based study. Cent Eur J Public Health. 2006;14:78-81.
- 13 Arias-Santiago S, Guttierrez-Salmeron MT, Castellote- Caballero L, Buendia- Eisman A, Naranjo-Sintes R. Male Androgenetic Alopecia and Cardiovascular Risk Factors: A Case-Control Study. Actas Dermosifiliogr 2010;101(3):248-256.
- Nabaie L, Kavand S, Robati RM, Sarrafi-Rad N, Kavand S, Shahgholi L, et al. Androgenic alopecia and insulin resistance: Are they really related? Clin Exp Dermatol 2009;34:694-7.
- Guzzo CA, Margolis DJ, Johnson J. Lipid profiles, alopecia, and coronary disease: Any relationship? Dermatol Surg 1996;22:481.
How to Cite This Article
Vancouver
Swaroop MR, BK M, Sathyanarayana B, D Y, JC R. The association of metabolic syndrome and insulin resistance in early-onset androgenetic alopecia in males: a case-control study [Internet]. IP Indian J Clin Exp Dermatol. 2016 [cited 2025 Oct 14];2(4):159-163. Available from: https://doi.org/
APA
Swaroop, M. R., BK, M., Sathyanarayana, B., D, Y., JC, R. (2016). The association of metabolic syndrome and insulin resistance in early-onset androgenetic alopecia in males: a case-control study. IP Indian J Clin Exp Dermatol, 2(4), 159-163. https://doi.org/
MLA
Swaroop, M. Ranga, BK, Manohara, Sathyanarayana, BD, D, Yogesh, JC, Raghavendra. "The association of metabolic syndrome and insulin resistance in early-onset androgenetic alopecia in males: a case-control study." IP Indian J Clin Exp Dermatol, vol. 2, no. 4, 2016, pp. 159-163. https://doi.org/
Chicago
Swaroop, M. R., BK, M., Sathyanarayana, B., D, Y., JC, R.. "The association of metabolic syndrome and insulin resistance in early-onset androgenetic alopecia in males: a case-control study." IP Indian J Clin Exp Dermatol 2, no. 4 (2016): 159-163. https://doi.org/